moxifloxacin

mox-i-FLOX-a-sin hye-droe-KLOR-ide

Oral route(Tablet)

Fluoroquinolones, including moxifloxacin hydrochloride, are associated with an increased risk of tendinitis and tendon rupture in all ages. Risk further increases with age over 60 years, concomitant steroid therapy, and kidney, heart, or lung transplants. Fluoroquinolones, including moxifloxacin hydrochloride, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid in patients with known history of myasthenia gravis .

Commonly used brand name(s)

In the U.S.

• Avelox

Available Dosage Forms:

• Tablet

Therapeutic Class: Antibiotic

Chemical Class: Moxifloxacin

Uses For moxifloxacin

Moxifloxacin is used to treat bacterial infections in many different parts of the body.

Moxifloxacin belongs to the class of medicines known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, moxifloxacin will not work for colds, flu, or other virus infections.

moxifloxacin is available only with your doctor's prescription.

Before Using moxifloxacin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For moxifloxacin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to moxifloxacin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of moxifloxacin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of moxifloxacin in the elderly. However, elderly patients are more likely to have age-related heart problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving moxifloxacin.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking moxifloxacin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using moxifloxacin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Dronedarone


• Mesoridazine


• Pimozide


• Sparfloxacin


• Thioridazine


• Ziprasidone

Using moxifloxacin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose


• Acetohexamide


• Acetophenazine


• Alfuzosin


• Amiodarone


• Amitriptyline


• Amoxapine


• Apomorphine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Azithromycin


• Benfluorex


• Bretylium


• Chloroquine


• Chlorpromazine


• Chlorpropamide


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clozapine


• Crizotinib


• Dasatinib


• Desipramine


• Disopyramide


• Dofetilide


• Dolasetron


• Dothiepin


• Doxepin


• Droperidol


• Erythromycin


• Ethopropazine


• Flecainide


• Fluconazole


• Fluphenazine


• Gatifloxacin


• Gemifloxacin


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Granisetron


• Guar Gum


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Imipramine


• Insulin


• Insulin Aspart, Recombinant


• Insulin Glulisine


• Insulin Lispro, Recombinant


• Lapatinib


• Levofloxacin


• Lofepramine


• Lopinavir


• Lumefantrine


• Mefloquine


• Metformin


• Methadone


• Methotrimeprazine


• Miglitol


• Moricizine


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Opipramol


• Paliperidone


• Pazopanib


• Perflutren Lipid Microsphere


• Perphenazine


• Pipotiazine


• Posaconazole


• Procainamide


• Prochlorperazine


• Promazine


• Promethazine


• Propafenone


• Propiomazine


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Salmeterol


• Saquinavir


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Sunitinib


• Telavancin


• Telithromycin


• Terfenadine


• Tetrabenazine


• Thiethylperazine


• Tolazamide


• Tolbutamide


• Toremifene


• Trazodone


• Trifluoperazine


• Triflupromazine


• Trimeprazine


• Trimipramine


• Troglitazone


• Vandetanib


• Vardenafil


• Vemurafenib


• Voriconazole


• Warfarin

Using moxifloxacin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aluminum Carbonate, Basic


• Aluminum Hydroxide


• Aluminum Phosphate


• Betamethasone


• Corticotropin


• Cortisone


• Cosyntropin


• Deflazacort


• Dexamethasone


• Didanosine


• Dihydroxyaluminum Aminoacetate


• Dihydroxyaluminum Sodium Carbonate


• Fludrocortisone


• Fluocortolone


• Hydrocortisone


• Iron


• Magaldrate


• Magnesium Carbonate


• Magnesium Hydroxide


• Magnesium Oxide


• Magnesium Trisilicate


• Methylprednisolone


• Paramethasone


• Prednisolone


• Prednisone


• Rifampin


• Sucralfate


• Triamcinolone


• Zinc

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of moxifloxacin. Make sure you tell your doctor if you have any other medical problems, especially:

• Bradycardia (slow heartbeat) or


• Depression or


• Diarrhea or


• Heart attack, recent or


• Heart rhythm problems (eg, prolonged QT interval) or


• Seizures (epilepsy), history of—Use with caution. May make these conditions worse.

• Brain disease (eg, hardening of the arteries) or


• Kidney disease or


• Liver disease (including cirrhosis) or


• Organ transplant (eg, heart, kidney, or lung), history of or


• Tendon disorder (eg, rheumatoid arthritis), history of—Use with caution. May cause side effects to become worse.

• Hypokalemia (low potassium in the blood) or


• Myasthenia gravis (severe muscle weakness)—Should not be used in patients with these conditions.

Proper Use of moxifloxacin

Take moxifloxacin only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

moxifloxacin comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Swallow the tablet whole with a glass of water. Do not split, crush or chew it. moxifloxacin may be taken with or without food.

Take moxifloxacin at the same time each day.

Drink plenty of fluids with moxifloxacin to help prevent some unwanted effects.

If you are taking aluminum or magnesium-containing antacids, iron supplements, multivitamins, didanosine (Videx®), sucralfate (Carafate®), or zinc, do not take them at the same time that you take moxifloxacin. It is best to take these medicines at least 4 hours before or 8 hours after taking moxifloxacin. These medicines may keep moxifloxacin from working properly.

Keep using moxifloxacin for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of moxifloxacin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of moxifloxacin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For infections:
    
    • Adults—400 milligrams (mg) once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of moxifloxacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using moxifloxacin

It is very important that your doctor check your progress while you are taking moxifloxacin. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

If you have low potassium levels in the blood, moxifloxacin may increase your risk of having a fast, slow or irregular heartbeat; loss of consciousness; or fainting spells. If these symptoms occur, tell your doctor right away.

moxifloxacin may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you take moxifloxacin.

Moxifloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking moxifloxacin. Do not take any medicine to treat diarrhea without checking first with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

Moxifloxacin may rarely cause inflammation (tendinitis) or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are taking the medicine or after you finish taking it. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (eg, dexamethasone, prednisolone, prednisone, or Medrol®), have severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or if you have received an organ transplant (eg, heart, kidney, or lung). Stop using moxifloxacin and check with your doctor right away if you have sudden pain or swelling in a tendon after exercise (eg, ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.

Moxifloxacin may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to moxifloxacin before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If these reactions are especially bothersome, check with your doctor.

Some people who take moxifloxacin may become more sensitive to sunlight than normal. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you begin using moxifloxacin:

• Stay out of direct sunlight, especially between the hours of 10 AM and 3 PM, if possible.


• Wear protective clothing, including a hat and sunglasses.


• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.


• Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

moxifloxacin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Abdominal or stomach cramps


• abdominal or stomach tenderness


• black, tarry stools


• bleeding gums


• blisters


• bloating or swelling of the face, arms, hands, lower legs, or feet


• blood in the urine or stools


• blurred vision


• bone pain


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain


• chills


• clay-colored stools


• cough


• crying


• dark urine


• diarrhea, watery and severe, which may also be bloody


• difficult or labored breathing


• difficulty with moving


• difficulty with swallowing


• discouragement


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• dry mouth


• excessive muscle tone


• fainting


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling of unreality


• feeling of warmth or heat


• feeling sad or empty


• fever


• flushed, dry skin


• flushing or redness of the skin, especially on the face and neck


• fruit-like breath odor


• headache


• hyperventilation


• increased hunger


• increased sensitivity of the skin to sunlight


• increased thirst


• increased urination


• irregular heartbeat recurrent


• irritability


• itching


• joint pain, stiffness, or swelling


• lack of coordination


• loss of appetite


• loss of interest or pleasure


• lower back, side, or stomach pain


• mood or mental changes


• muscle aching or cramping


• muscle pains or stiffness


• muscle tension or tightness


• nausea or vomiting


• nervousness


• noisy breathing


• pain


• pain in the pelvis


• pain, warmth, or burning in the fingers, toes, and legs


• painful or difficult urination


• painful, swollen joints


• pale skin


• palpitations


• pinpoint red spots on the skin


• pounding in the ears


• problems with speech or speaking


• problems with vision or hearing


• quick to react or overreact emotionally


• rapid weight gain


• rapidly changing moods


• redness or other discoloration of the skin


• restlessness


• seeing, hearing, or feeling things that are not there


• seizures


• sensation of the skin burning


• sense of detachment from self or body


• severe sunburn


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• sweating


• swelling of the feet or lower legs


• swelling or puffiness of the face


• swollen glands


• tightness in the chest


• tingling of the hands or feet


• tiredness


• trouble concentrating


• trouble sleeping


• troubled breathing with exertion


• unexplained weight loss


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight gain or loss


• vomiting of blood


• wheezing


• yellow eyes or skin

Incidence not known

• Blistering, peeling, or loosening of the skin


• change in the ability to see colors, especially blue or yellow


• difficulty in chewing or talking


• double vision


• drooping eyelids


• eye pain


• general feeling of tiredness or weakness


• hives


• hoarseness


• irregular or slow heart rate


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• light-colored stools


• muscle weakness


• no blood pressure or pulse


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red, irritated eyes


• red skin lesions, often with a purple center


• severe headache


• severe tiredness


• stomach pain, continuing


• stopping of heart


• unconsciousness


• unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Acid or sour stomach


• bad, unusual, or unpleasant (after) taste


• belching


• burning feeling in the chest or stomach


• change in sense of smell


• change in taste


• changes in vision


• continuing ringing or buzzing or other unexplained noise in the ears


• difficulty having a bowel movement (stool)


• excess air or gas in the stomach or intestines


• fear or nervousness


• feeling of constant movement of self or surroundings


• full feeling


• general feeling of discomfort or illness


• hearing loss


• heartburn


• impaired vision


• indigestion


• itching of the vagina or genital area


• lack or loss of strength


• loss of memory


• pain during sexual intercourse


• passing of gas


• problems with memory


• redness, swelling, or soreness of the tongue


• sensation of spinning


• sleepiness or unusual drowsiness


• sleeplessness


• sore mouth or tongue


• stomach discomfort, upset, or pain


• swelling or inflammation of the mouth


• thick, white vaginal discharge with no odor or with a mild odor


• unable to sleep


• vaginal yeast infection


• white patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More moxifloxacin resources

• Moxifloxacin Dosage
• Moxifloxacin Use in Pregnancy & Breastfeeding
• Moxifloxacin Drug Interactions
• Moxifloxacin Support Group
• 97 Reviews for Moxifloxacin - Add your own review/rating

• Moxifloxacin MedFacts Consumer Leaflet (Wolters Kluwer)


• Avelox Monograph (AHFS DI)


• Avelox Consumer Overview


• Avelox Prescribing Information (FDA)


• Avelox I.V.

Compare moxifloxacin with other medications

• Anthrax
• Anthrax Prophylaxis
• Bacterial Infection
• Bronchitis
• Intraabdominal Infection
• Pneumonia
• Prostatitis
• Sinusitis
• Skin and Structure Infection
• Skin Infection
• Tuberculosis, Active

Medicone Maximum Strength

Generic Name: benzocaine topical (BENZ oh kane TOP ik al)

Brand Names: Americaine, Americaine Hemorrhoidal, Anacaine, Anbesol Gel, Anbesol Liquid, Babee Teething Lotion, Benzo-O-Stetic, Boil Ease Pain Relieving, Cepacol Extra Strength, Cepacol Fizzlers, Dent-O-Kain, Dermoplast, Detane, Hurricaine, Lanacane, Maintain, Medicone Maximum Strength, Num-Zit, Numzident, Orabase, Orabase Gel-B, Orajel, Orajel Denture, Oral Pain Relief, OraMagic Plus, Outgro Pain Relief, Retre-Gel, Rid-A-Pain, Skeeter Stik, Solarcaine Aerosol, Sting-Kill, Topex, Trocaine, Vagisil Feminine Cream, zilactin-B

What is Medicone Maximum Strength (benzocaine topical)?

Benzocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, teething pain, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body. Benzocaine is also used to numb the skin or surfaces inside the mouth, nose, throat, vagina, or rectum to lessen the pain of inserting a medical instrument such as a tube or speculum.

There are many brands and forms of benzocaine topical available and not all brands are listed on this leaflet.

Benzocaine topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Medicone Maximum Strength (benzocaine topical)?

There are many brands and forms of benzocaine topical available and not all brands are listed on this leaflet.

Benzocaine topical used in the mouth or throat may cause a life-threatening condition in which the amount of oxygen in your blood stream becomes dangerously low. This condition is called methemoglobinemia (met-HEEM-oh glo-bin-EE-mee-a) and it may occur after only one use of benzocaine or after several uses.

Signs and symptoms of methemoglobinemia may occur within minutes or up to 2 hours after using benzocaine topical in the mouth or throat. GET EMERGENCY MEDICAL HELP IF YOU HAVE ANY OF THESE SYMPTOMS: headache, tired feeling, confusion, fast heart rate, and feeling light-headed or short of breath, with a pale, blue, or gray appearance of your skin, lips, or fingernails.

Do not use benzocaine topical if you have ever had methemoglobinemia in the past. Do not use this medicine on a child younger than 2 years old without medical advice. An overdose of numbing medications can cause fatal side effects if too much of the medicine is absorbed through your skin and into your blood. This is more likely to occur when using a numbing medicine without the advice of a medical doctor (such as during a cosmetic procedure like laser hair removal). Overdose symptoms may include uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

Use the smallest amount of this medication needed to numb the skin or relieve pain. Do not use large amounts of benzocaine topical, or cover treated skin areas with a bandage or plastic wrap without medical advice. Be aware that many cosmetic procedures are performed without a medical doctor present.

Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Before using benzocaine topical, tell your doctor if you have any type of inherited enzyme deficiency, heart disease, a breathing disorder such as asthma, bronchitis, or emphysema, or if you smoke.

If you are treating a sore throat, call your doctor if the pain is severe or lasts longer than 2 days, especially if you also develop a fever, headache, skin rash, swelling, nausea, vomiting, cough, or breathing problems.

What should I discuss with my health care provider before using Medicone Maximum Strength (benzocaine topical)?

Do not use benzocaine topical if you have ever had methemoglobinemia in the past. An overdose of numbing medications can cause fatal side effects if too much of the medicine is absorbed through your skin and into your blood. This is more likely to occur when using a numbing medicine without the advice of a medical doctor (such as during a cosmetic procedure like laser hair removal). Overdose symptoms may include uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  asthma, bronchitis, emphysema, or other breathing disorder;

  
  


• 
  

  heart disease;

  
  


• 
  

  a personal or family history of methemoglobinemia, or any genetic (inherited) enzyme deficiency; or

  
  


• 
  

  if you smoke.

  
  

FDA pregnancy category C. It is not known whether benzocaine topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.. It is not known whether benzocaine topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medicine on a child younger than 2 years old without medical advice.

How should I use Medicone Maximum Strength (benzocaine topical)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Use the smallest amount of medicine needed to numb the skin or relieve pain. Do not use large amounts of benzocaine topical, or cover treated skin areas with a bandage or plastic wrap without medical advice. Be aware that many cosmetic procedures are performed without a medical doctor present.

This medication comes with instructions for safe and effective application. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

To treat minor skin conditions, apply a thin layer of benzocaine topical to the affected area up to 4 times per day. If using the spray, hold the container 6 to 12 inches away from the skin. Do not spray this medication onto your face. Spray it instead on your hands and then rub it onto the face, avoiding contact with your eyes.

To treat hemorrhoids, clean the area with soap and water before applying benzocaine topical. Apply the medication up to 6 times per day. If you are using the rectal suppository, try to empty your bowel and bladder before inserting the suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

Do not use benzocaine topical to treat large skin areas or deep puncture wounds. Avoid using the medicine on skin that is raw or blistered, such as a severe burn or abrasion.

Call your doctor if your symptoms do not improve or if they get worse within the first 7 days of using benzocaine topical. Also call your doctor if your symptoms had cleared up but then came back.

If you are treating a sore throat, call your doctor if the pain is severe or lasts longer than 2 days, especially if you also develop a fever, headache, skin rash, swelling, nausea, vomiting, cough, or breathing problems.

Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

Since benzocaine topical is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of benzocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

What should I avoid while taking Medicone Maximum Strength (benzocaine topical)?

Avoid eating within 1 hour after using benzocaine topical on your gums or inside your mouth.

Benzocaine topical is for use only on the surface of your body, or just inside the mouth, vagina, or rectum. Avoid getting this medication in your eyes. Avoid swallowing the gel, liquid, or ointment while applying it to your gums or the inside of your mouth. The throat spray or oral lozenge may be swallowed gradually during use.

Do not apply other medications to the same affected areas you treat with benzocaine topical, unless your doctor has told you otherwise.

Medicone Maximum Strength (benzocaine topical) side effects

Benzocaine topical used in the mouth or throat may cause a life-threatening condition in which the amount of oxygen in your blood stream becomes dangerously low. This condition is called methemoglobinemia (met-HEEM-oh glo-bin-EE-mee-a) and it may occur after only one use of benzocaine or after several uses.

Signs and symptoms may occur within minutes or up to 2 hours after using benzocaine topical in the mouth or throat. GET EMERGENCY MEDICAL HELP IF YOU HAVE:

• 
  

  headache, tired feeling, confusion;

  
  


• 
  

  fast heart rate;

  
  


• 
  

  feeling light-headed or short of breath; and

  
  


• 
  

  pale, blue, or gray appearance of your skin, lips, or fingernails.

  
  

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using benzocaine topical and call your doctor at once if you have any of these other serious side effects:

• 
  

  headache, weakness, dizziness, breathing problems, fast heart rate, and gray or bluish colored skin (rare but serious side effects of benzocaine);

  
  


• 
  

  severe burning, stinging, or sensitivity where the medicine is applied;

  
  


• 
  

  swelling, warmth, or redness; or

  
  


• 
  

  oozing, blistering, or any signs of infection.

  
  

Less serious side effects may include:

• 
  

  mild stinging, burning, or itching where the medicine is applied;

  
  


• 
  

  skin tenderness or redness; or

  
  


• 
  

  dry white flakes where the medicine was applied.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Medicone Maximum Strength (benzocaine topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied benzocaine topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Medicone Maximum Strength resources

• Medicone Maximum Strength Side Effects (in more detail)
• Medicone Maximum Strength Use in Pregnancy & Breastfeeding
• Medicone Maximum Strength Support Group
• 0 Reviews · Be the first to review/rate this drug

• Americaine Ointment MedFacts Consumer Leaflet (Wolters Kluwer)


• Anacaine Advanced Consumer (Micromedex) - Includes Dosage Information


• Anbesol Extra Strength Advanced Consumer (Micromedex) - Includes Dosage Information


• Benz-O-Sthetic Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Lanacane Aerosol Spray MedFacts Consumer Leaflet (Wolters Kluwer)


• OraMagic Plus Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Rid-A-Pain Topical Advanced Consumer (Micromedex) - Includes Dosage Information

Where can I get more information?

• Your pharmacist can provide more information about benzocaine topical.

See also: Medicone Maximum Strength side effects (in more detail)

Metformin Solution

Pronunciation: met-FOR-min
Generic Name: Metformin
Brand Name: Riomet

Metformin Solution may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Metformin Solution.

Do not begin to take Metformin Solution if you are 80 years or older unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Metformin Solution before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as muscle pain or tenderness; unusual drowsiness, dizziness, or light-headedness; slow or irregular heartbeat; fast or difficult breathing; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold or if you have a general feeling of being unwell.

Metformin Solution is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Metformin Solution is a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

Do NOT use Metformin Solution if:

• you are allergic to any ingredient in Metformin Solution


• you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (eg, diabetic ketoacidosis), or dehydration


• you have had a stroke, a recent heart attack, or you are in shock


• you are 80 years or older and have not had a kidney function test


• you will be having surgery or certain lab procedures

Contact your doctor or health care provider right away if any of these apply to you.

Before using Metformin Solution:

Some medical conditions may interact with Metformin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart failure, especially heart failure that is treated by medicine


• if you have a history of heart problems, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, or lactic acidosis


• if you have vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you are dehydrated


• if you have an infection, fever, recent injury, or moderate to severe burns


• if you drink alcohol or have a history of alcohol abuse


• if you will be having surgery or certain lab procedures


• if you take a beta-blocker (eg, propranolol)

Some MEDICINES MAY INTERACT with Metformin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin, or medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, tacrolimus) because they may increase the risk of Metformin Solution's side effects. Ask you doctor if you are unsure if any of your medicines might harm the kidney


• Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, phenothiazine (eg, chlorpromazine), phenytoin, sulfonylureas (eg, glipizide), sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metformin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metformin Solution:

Use Metformin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Metformin Solution by mouth with food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Take Metformin Solution on a regular schedule to get the most benefit from it. Taking Metformin Solution at the same time each day will help you remember to take it.


• Continue to take Metformin Solution even if you feel well. Do not miss any doses.


• If you miss a dose of Metformin Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metformin Solution.

Important safety information:

• Metformin Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Metformin Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it


• Follow the diet and exercise program given to you by your health care provider.


• Do not drink large amounts of alcohol while you take Metformin Solution. Talk to your doctor or health care provider before you drink alcohol while you take Metformin Solution.


• Tell your doctor or dentist that you take Metformin Solution before you receive any medical or dental care, emergency care, or surgery.


• Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Metformin Solution's side effects.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Metformin Solution exactly as prescribed, tell your doctor.


• Metformin Solution does not usually cause low blood sugar. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Metformin Solution along with certain medicines for diabetes (eg, sulfonylureas, insulin). Tell your doctor right away if you experience symptoms of low blood sugar (eg, fast heartbeat, headache, chills, sweating, tremors, increased hunger, vision changes, nervousness, weakness, dizziness, drowsiness, fainting).


• It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.


• Fever, infection, injury, or surgery may increase your risk of high or low blood sugar levels. If any of these occur, check your blood sugar level closely and tell your doctor right away.


• Metformin Solution may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.


• Lab tests, including kidney function, fasting blood glucose, hemoglobin A_1c, and complete blood cell counts, may be performed while you take Metformin Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Metformin Solution with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.


• Metformin Solution should not be used in CHILDREN younger than 10 years; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Metformin Solution while you are pregnant. It is not known if Metformin Solution is found in breast milk. Do not breast-feed while taking Metformin Solution.

When used for long periods of time, Metformin Solution may not work as well. If your blood sugar has been under control and then becomes hard to manage, contact your doctor. Do not change the dose of your medicine without checking with your doctor.

Possible side effects of Metformin Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Metformin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Metformin Solution:

Store Metformin Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metformin Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Metformin Solution, please talk with your doctor, pharmacist, or other health care provider.


• Metformin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Metformin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Metformin resources

• Metformin Side Effects (in more detail)
• Metformin Use in Pregnancy & Breastfeeding
• Drug Images
• Metformin Drug Interactions
• Metformin Support Group
• 90 Reviews for Metformin - Add your own review/rating

Compare Metformin with other medications

• Diabetes, Type 2
• Female Infertility
• Insulin Resistance Syndrome
• Polycystic Ovary Syndrome

Boots Anaesthetic & Antibiotic Throat Lozenges

1. Name Of The Medicinal Product

Boots Anaesthetic and Antibiotic Throat Lozenges

2. Qualitative And Quantitative Composition

Active ingredient
Tyrothricin USP	1.0 mg/lozenge
Benzocaine BP Fine Pdr Ph Eur	5.0 mg/lozenge

3. Pharmaceutical Form

Tablet

4. Clinical Particulars

4.1 Therapeutic Indications

For the relief of sore throats.

For oral administration.

4.2 Posology And Method Of Administration

Adults and children over 12 years: one lozenge to be sucked slowly as required. Not more than eight lozenges to be taken in any one day.

Children under 12 years: not suitable for children under 12 years.

Elderly: The normal adult dose is still appropriate in the elderly.

4.3 Contraindications

Hypersensitivity to ester type local anaesthetics or the antibiotic tyrothricin, or any of the other ingredients.

4.4 Special Warnings And Precautions For Use

Boots Anaesthetic and Antibiotic Throat Lozenges should be used with caution in patients with myasthenia gravis, patients with low plasma cholinesterase concentrations or in those receiving anticholinesterases.

If symptoms persist consult your doctor.

Warning: do no exceed the stated dose.

Keep all medicines out of the reach of children.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

These lozenges may interfere with the action of sulphonamides.

4.6 Pregnancy And Lactation

The safety of Boots Anaesthetic and Antibiotic Throat Lozenges during pregnancy and lactation has not been established. As local anaesthetics can cross the placenta, it is recommended that this product is not taken during pregnancy.

No information on the use of this product in lactation is available and it is recommended that this product is not taken whilst breast feeding.

4.7 Effects On Ability To Drive And Use Machines

No adverse effects known.

4.8 Undesirable Effects

Occasional hypersensitivity reaction and soreness of the tongue. Methaemoglobinaemia can rarely occur.

4.9 Overdose

Overdosage with Boots Anaesthetic and Antibiotic Throat Lozenges will produce excessive anaesthesia in the upper alimentary tract. Treatment should be symptomatic and supportive. Gastric lavage and emesis may be required.

In severe overdosage, methaemoglobinaemia may occur and should be treated by intravenous administration of 1% solution of methylene blue in a dose of 1-4 mg per kg of bodyweight.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Tyrothricin is an antibiotic. It is a mixture consisting of gramicidin and tyrocidine, both components being mixtures of polypeptides. It is active against many gram positive bacteria.

Benzocaine is a local anaesthetic of the ester type, used exclusively for surface anaesthesia.

5.2 Pharmacokinetic Properties

Not applicable

5.3 Preclinical Safety Data

Not applicable

6. Pharmaceutical Particulars

6.1 List Of Excipients

Sodium Chloride

Icing sugar

Industrial methylated spirit

Acacia pdrd sieved

Purified water

Clove leaf oil

Star anise Oil

Isopropyl alcohol

Magnesium stearate

Carmine extract OF63

6.2 Incompatibilities

Not applicable

6.3 Shelf Life

24 months

6.4 Special Precautions For Storage

Do not store above 25EC.

6.5 Nature And Contents Of Container

A push-through blister pack consisting of a clear PVC blister heat sealed to aluminium foil, each carton contains 24 lozenges contained in a cardboard carton.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

The Boots Company PLC

1 Thane Road West

Nottingham NG2 3AA

8. Marketing Authorisation Number(S)

PL 0014/5172R

9. Date Of First Authorisation/Renewal Of The Authorisation

Date of last renewal: 19 November 1990

10. Date Of Revision Of The Text

February 2011

Eurax Hydrocortisone Cream (Novartis Consumer Health)

1. Name Of The Medicinal Product

Eurax^® Hydrocortisone Cream

2. Qualitative And Quantitative Composition

Active ingredients:	Crotamiton 10.0% w/w
	Hydrocortisone BP 0.25% w/w

For excipients see section 6.1

3. Pharmaceutical Form

Cream

4. Clinical Particulars

4.1 Therapeutic Indications

Eczema and dermatitis of all types including atopic eczema, photodermatitis, otitis externa, primary irritant and allergic dermatitis, intertrigo, prurigo nodularis, seborrhoeic dermatitis and insect bite reactions.

Route of Administration: Cutaneous use.

4.2 Posology And Method Of Administration

Adults

A thin layer of Eurax Hydrocortisone Cream should be applied to the affected area 2-3 times a day. Occlusive dressings should not be used. Treatment should be limited to 10-14 days or up to 7 days if applied to the face.

Use in the Elderly

Clinical evidence would indicate that no special dosage regime is necessary.

Use in Children

Eurax Hydrocortisone should be used with caution in infants and for not more than 7 days. Eurax Hydrocortisone should not be applied more than once a day to large areas of the body surface in young children.

4.3 Contraindications

Hypersensitivity to any component of the formulation. Bacterial, viral or fungal infections of the skin. Acute exudative dermatoses. Application to ulcerated areas.

4.4 Special Warnings And Precautions For Use

Eurax Hydrocortisone should be used with caution in infants and for not more than 7 days; long-term continuous topical therapy should be avoided since this can lead to adrenal suppression even without occlusion.

Eurax Hydrocortisone should not be allowed to come into contact with the conjunctiva and mucous membranes.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

There is inadequate evidence of safety in human pregnancy. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development, including cleft palate and intra-uterine growth retardation. There may therefore be a very small risk of such effects in the human foetus.

It is not known whether the active substances of Eurax Hydrocortisone and/or their metabolites pass into the breast milk after topical administration. Use in lactating mothers should only be at the doctor's discretion.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Occasionally at the site of application signs of irritation such as a burning sensation, itching, contact dermatitis/contact allergy may occur. Treatment should be discontinued if patients experience severe irritation or sensitisation.

4.9 Overdose

Eurax Hydrocortisone is for application to the skin only. If accidental ingestion of large quantities occurs, there is no specific antidote and general measures to eliminate the drug and reduce its absorption should be undertaken. Symptomatic treatment should be administered as appropriate.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Eurax Hydrocortisone combines the antipruritic action of crotamiton with the anti-inflammatory and anti-allergic properties of hydrocortisone.

5.2 Pharmacokinetic Properties

No pharmacokinetic data on Eurax Hydrocortisone Cream are available.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Stearyl alcohol

White soft paraffin

Polyoxy 40 stearate

Propyl hydroxybenzoate

Propylene glycol

Methyl hydroxybenzoate

Perfume Givaudan no 45

Sulphuric acid

Purified water

6.2 Incompatibilities

None known

6.3 Shelf Life

30 months

6.4 Special Precautions For Storage

Do not store above 25^○C

6.5 Nature And Contents Of Container

Collapsible aluminium tube

Pack Size: 30g

6.6 Special Precautions For Disposal And Other Handling

Medicines should be kept out of the reach and sight of children.

7. Marketing Authorisation Holder

Novartis Consumer Health UK Ltd

Trading as

Novartis Consumer Health

Wimblehurst Road

Horsham

West Sussex

RH12 5AB

8. Marketing Authorisation Number(S)

PL 00030/0094

9. Date Of First Authorisation/Renewal Of The Authorisation

Original grant date: 17 January 1991

Date of renewal: 17 January 1996

10. Date Of Revision Of The Text

22 December 2009

Legal category: POM

Serevent Diskus

Generic Name: salmeterol (Inhalation route)

sal-ME-ter-ol zye-NAF-oh-ate

Commonly used brand name(s)

In the U.S.

• Serevent

In Canada

• Serevent Diskhaler Disk


• Serevent Diskus


• Severent


• Severent Diskhaler


• Severent Diskus

Available Dosage Forms:

• Powder


• Disk


• Aerosol Powder

Therapeutic Class: Bronchodilator

Pharmacologic Class: Salmeterol

Uses For Serevent Diskus

Salmeterol is used together with other medicines (such as inhaled corticosteroids) to treat asthma and prevent bronchospasm in patients with asthma. When used regularly every day, inhaled salmeterol decreases the number and severity of asthma attacks. However, it will not relieve an asthma attack that has already started.

Salmeterol is also used to treat air flow blockage and prevent the worsening of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. This medicine is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm or EIB).

Salmeterol is a long-acting bronchodilator. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Before Using Serevent Diskus

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of salmeterol in children above 4 years of age. Safety and efficacy have not been established in children younger than 4 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of salmeterol in the elderly. However, elderly patients with heart problems may require special caution when receiving salmeterol.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Dronedarone


• Fluconazole


• Mesoridazine


• Pimozide


• Posaconazole


• Sparfloxacin


• Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alfuzosin


• Alprenolol


• Amiodarone


• Apomorphine


• Arotinolol


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atazanavir


• Atenolol


• Azithromycin


• Befunolol


• Betaxolol


• Bevantolol


• Bisoprolol


• Boceprevir


• Bopindolol


• Brofaromine


• Bucindolol


• Bupranolol


• Carteolol


• Carvedilol


• Celiprolol


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clorgyline


• Clozapine


• Crizotinib


• Darunavir


• Dasatinib


• Dilevalol


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Esmolol


• Flecainide


• Fosamprenavir


• Furazolidone


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Indinavir


• Iproniazid


• Isocarboxazid


• Itraconazole


• Ketoconazole


• Labetalol


• Landiolol


• Lapatinib


• Lazabemide


• Levobetaxolol


• Levobunolol


• Levofloxacin


• Linezolid


• Lopinavir


• Lumefantrine


• Mefloquine


• Mepindolol


• Methadone


• Metipranolol


• Metoprolol


• Moclobemide


• Moxifloxacin


• Nadolol


• Nebivolol


• Nefazodone


• Nelfinavir


• Nialamide


• Nilotinib


• Nipradilol


• Norfloxacin


• Octreotide


• Ofloxacin


• Ondansetron


• Oxprenolol


• Paliperidone


• Pargyline


• Pazopanib


• Penbutolol


• Perflutren Lipid Microsphere


• Phenelzine


• Pindolol


• Procainamide


• Procarbazine


• Prochlorperazine


• Promethazine


• Propafenone


• Propranolol


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Rasagiline


• Ritonavir


• Saquinavir


• Selegiline


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Sunitinib


• Talinolol


• Telaprevir


• Telavancin


• Telithromycin


• Terfenadine


• Tertatolol


• Tetrabenazine


• Timolol


• Tipranavir


• Toloxatone


• Toremifene


• Tranylcypromine


• Trazodone


• Trifluoperazine


• Vandetanib


• Vardenafil


• Vemurafenib


• Voriconazole


• Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Erythromycin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma attack, acute or


• Bronchospasm (difficulty with breathing), acute or


• COPD flare-up—Should not be used in patients with these conditions.

• Diabetes or


• Heart or blood vessel disease or


• Heart rhythm problems (e.g., arrhythmia, QT prolongation) or


• Hypertension (high blood pressure) or


• Hyperthyroidism (overactive thyroid) or


• Hypokalemia (low potassium in the blood) or


• Ketoacidosis (high ketones in the blood) or


• Seizures, history of—Use with caution. May make these conditions worse.

Proper Use of salmeterol

This section provides information on the proper use of a number of products that contain salmeterol. It may not be specific to Serevent Diskus. Please read with care.

Inhaled salmeterol is used to prevent asthma attacks and to treat chronic obstructive pulmonary disease (COPD). It is not used to relieve an asthma attack that has already started. For relief of an asthma attack that has already started, you should use another medicine. If you do not have another medicine to use for an attack or if you have any questions about this, check with your doctor.

This medicine comes with patient directions or a medication guide. Read the directions carefully before using this medicine. If you do not understand the directions or you are not sure how to use the Diskus®, ask your doctor or pharmacist to show you what to do.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may increase the chance of having breathing problems.

In order for this medicine to help prevent asthma or COPD attacks, it must be used every day in regularly spaced doses, as ordered by your doctor.

To use the Diskus®:

• Open the foil pouch containing the Diskus®.


• To open the Diskus®, push the thumb grip away from you as far as it will go. You will hear a click and feel a snap. When open, the mouthpiece will appear.


• Slide the mouthpiece lever away from you as far as it will go until it clicks. The Diskus® is now ready to use. If you close the Diskus® or push the lever again, you will lose medicine.


• Turn your head away from the Diskus®, and breathe out to the end of a normal breath. Do not breathe into the Diskus®.


• Holding the Diskus® level, put the mouthpiece between your lips and teeth, and close your lips around the mouthpiece. Do not bite down on the mouthpiece. Do not block the mouthpiece with your teeth or tongue.


• Breathe in through your mouth as deeply as you can until you have taken a full deep breath. Do not breathe through your nose.


• Hold your breath and remove the mouthpiece from your mouth. Continue holding your breath as long as you can up to 10 seconds before breathing out slowly. This gives the medicine time to settle in your airways and lungs.


• Turn your head away from the Diskus®, and breathe out slowly to the end of a normal breath. Do not breathe into the Diskus®.


• If your doctor has told you to inhale more than one puff of medicine at each dose, take the second puff using exactly the same steps you used for the first puff.


• When you are finished, close the Diskus®. Place your thumb on the thumb grip, and slide it back toward you as far as it will go. You will hear it click shut.


• Keep the Diskus® dry. Do not wash the mouthpiece, or any other part of the Diskus®. You may use a dry cloth to wipe it clean.


• The Diskus® has a window that shows the number of doses that are left. This tells you when you are getting low on medicine. When the Diskus® has 5 doses left, the numbers from 5 to 0 will show up in red to remind you to refill your prescription.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inhalation dosage form (powder):
  
  • For preventing an asthma attack:
    
    • Adults, teenagers, and children 4 years of age and older—One inhalation (50 micrograms [mcg]) two times per day (morning and evening). The doses should be at least 12 hours apart.
    
    
    • Children younger than 4 years of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For maintenance treatment of COPD:
    
    • Adults—One inhalation (50 micrograms [mcg]) two times per day (morning and evening). The doses should be at least 12 hours apart.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For preventing exercise-induced bronchospasm (EIB):
    
    • Adults, teenagers, and children 4 years of age and older—One inhalation (50 micrograms [mcg]) taken 30 minutes before exercise.
    
    
    • Children younger than 4 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw the medicine away 6 weeks after it is removed from the foil pouch or after all the blisters have been used.

Precautions While Using Serevent Diskus

If you will be taking this medicine for a long time, it is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

Tell your doctor if you are also using other medicines for your COPD. Your doctor may want you to stop using the medicine and use it only during a severe COPD attack. Follow your doctor's instructions on how you should take your medicine.

This medicine should not be used if you are having a severe COPD attack, or if symptoms of COPD attack has already started. Your doctor may prescribe another medicine for you to use in case of an acute COPD attack. If the other medicine does not work as well, tell your doctor right away.

This medicine should only be used as an additional treatment for patients who cannot be treated with other asthma medicines (such as inhaled corticosteroids) or for asthma patients that require two medicines, including salmeterol. Ask your doctor if you have any questions.

Although this medicine decreases the number of asthma attacks, it may increase the chance for a severe asthma attack when they do occur. Be sure to read about these risks in the Medication Guide and talk to your doctor or pharmacist about any questions or concerns you may have.

You should not use this medicine if your asthma attack has already started. Your doctor will prescribe another medicine (e.g., a short-acting inhaler) for you to use in case of an acute asthma attack. Make sure you understand how to use the short-acting inhaler. Talk to your doctor if you need instructions.

Do not use any other asthma medicine or medicine for breathing problems without talking to your doctor. This medicine should not be used with other inhalers that contain budesonide and formoterol combination (Symbicort®), fluticasone and salmeterol combination (e.g., Advair® Diskus®, Advair® HFA), formoterol (Foradil® Aerolizer®, Perforomist™), or arformoterol (Brovana™).

Talk to your doctor or get medical care right away if:

• Your or your child's symptoms do not improve after using this medicine for 1 week or if they become worse.


• Your short-acting inhaler does not seem to be working as well as usual and you or your child need to use it more often (e.g., you use 1 whole canister of the short-acting inhaler in 8 weeks time, or you need to use 4 or more inhalations of the short-acting inhaler for 2 or more days in a row).


• You or your child have a big decrease in your peak flow when measured as directed by your doctor.

Do not change your dose or stop using your medicine without first asking your doctor.

Your doctor may want you to carry a medical identification (ID) card stating that you or your child are using this medicine. The card will say that you may need additional medicine during an emergency, a severe asthma attack or other illness, or unusual stress.

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Stop using this medicine and check with your doctor right away if you or your child are having a cough, difficulty with breathing, shortness of breath, or wheezing after using this medicine.

If you or your child develop a skin rash, hives, or any allergic reaction to this medicine, stop using the medicine and check with your doctor as soon as possible.

Check with your doctor right away if you or your child have chest pain, a fast heartbeat, nervousness, shaking of the hands or feet, noisy breathing, a feeling of choking, or tightness or irritation of the throat while using this medicine.

Hypokalemia (low potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you or your child have more than one of the following symptoms: convulsions; decreased urine; dry mouth; increased thirst; irregular heartbeat; loss of appetite; mood changes; muscle pain or cramps; nausea or vomiting; numbness or tingling in the hands, feet, or lips; shortness of breath; or unusual tiredness or weakness.

This medicine may affect blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serevent Diskus Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Cough producing mucus


• difficulty with breathing


• headache


• irritation of the throat


• runny nose


• shortness of breath


• sneezing


• stuffy nose


• tightness in the chest


• wheezing

Less common

• Abdominal or stomach pain


• blurred vision


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chills


• colds


• cough or hoarseness


• diarrhea


• difficulty breathing


• dizziness


• dry mouth


• fever


• flu-like symptoms


• flushed, dry skin


• fruit-like breath odor


• general feeling of discomfort or illness


• increased hunger


• increased thirst


• increased urination


• joint pain


• loss of appetite


• muscle aches and pains


• nausea


• nervousness


• noisy breathing


• pain


• pain or tenderness around the eyes and cheekbones


• pounding in the ears


• shivering


• slow or fast heartbeat


• sore mouth or tongue


• sore throat


• sweating


• swelling


• trouble with sleeping


• troubled breathing


• unexplained weight loss


• unusual tiredness or weakness


• vomiting


• white patches in the mouth or on the tongue

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Arm, back, or jaw pain


• confusion


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• fainting


• fast or irregular heartbeat


• fast, slow, pounding, or irregular heartbeat or pulse


• seizures


• shakiness in the legs, arms, hands, or feet


• sleeplessness


• trembling or shaking of the hands or feet


• unable to sleep

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• anxiety


• belching


• blistering, burning, crusting, dryness, or flaking of the skin


• bone pain


• burning, dry, or itching eyes


• difficulty with moving


• discharge or excessive tearing


• eye redness, irritation, or pain


• headache, severe and throbbing


• heartburn


• hives or welts


• indigestion


• itching, scaling, severe redness, soreness, or swelling of the skin


• mouth or tooth pain


• muscle cramps and spasm


• muscle stiffness or tightness


• redness of the skin


• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid


• skin rash


• skin rash, encrusted, scaly and oozing


• stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Serevent Diskus side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Serevent Diskus resources

• Serevent Diskus Side Effects (in more detail)
• Serevent Diskus Use in Pregnancy & Breastfeeding
• Serevent Diskus Drug Interactions
• Serevent Diskus Support Group
• 0 Reviews for Serevent Diskus - Add your own review/rating

• Serevent Diskus Prescribing Information (FDA)


• Serevent Diskus MedFacts Consumer Leaflet (Wolters Kluwer)


• Salmeterol Professional Patient Advice (Wolters Kluwer)


• Salmeterol Xinafoate Monograph (AHFS DI)


• Serevent Consumer Overview


• Serevent Prescribing Information (FDA)


• Serevent diskus

Compare Serevent Diskus with other medications

• Asthma, Maintenance
• Bronchospasm Prophylaxis
• COPD, Maintenance

Acrivastine/Pseudoephedrine

Pronunciation: AK-ri-vas-teen/soo-doe-e-FED-rin
Generic Name: Acrivastine/Pseudoephedrine
Brand Name: Semprex-D

Acrivastine/Pseudoephedrine is used for:

Relieving symptoms associated with allergies, including sneezing, runny nose, itching, watery eyes, and nasal stuffiness. It may also be used for certain conditions as determined by your doctor.

Acrivastine/Pseudoephedrine is an antihistamine and decongestant combination. It works by blocking histamine at H₁ receptor sites and causes vasoconstriction and shrinkage of the nasal mucous membranes, which helps to promote nasal drainage and relieve watery eyes, runny nose, and sneezing.

Do NOT use Acrivastine/Pseudoephedrine if:

• you are allergic to any ingredient in Acrivastine/Pseudoephedrine


• you have severe high blood pressure or severe heart disease


• you are taking furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) or have taken an MAO inhibitor within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acrivastine/Pseudoephedrine:

Some medical conditions may interact with Acrivastine/Pseudoephedrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have high blood pressure, heart disease, diabetes, overactive thyroid, or glaucoma


• if you have kidney problems, blockage of the stomach or bowel, peptic ulcers, urinary tract problems, prostate disease, or difficulty urinating

Some MEDICINES MAY INTERACT with Acrivastine/Pseudoephedrine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), certain stimulants, (eg, albuterol, amphetamine, phenylephrine), furazolidone, or MAO inhibitors (eg, phenelzine), because side effects may be increased and potentially life-threatening high blood pressure may occur. Do NOT take MAO inhibitors or furazolidone within 2 weeks of taking Acrivastine/Pseudoephedrine


• Urinary alkalinizers (eg, sodium bicarbonate) because they may increase the actions and side effects of Acrivastine/Pseudoephedrine


• Certain blood pressure medicines (eg, guanethidine) because their effectiveness may be decreased by Acrivastine/Pseudoephedrine


• Bromocriptine because side effects may be increased by Acrivastine/Pseudoephedrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acrivastine/Pseudoephedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acrivastine/Pseudoephedrine:

Use Acrivastine/Pseudoephedrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Acrivastine/Pseudoephedrine may be taken with or without food.


• Swallow Acrivastine/Pseudoephedrine whole. Do not break, crush, or chew before swallowing.


• If you miss a dose of Acrivastine/Pseudoephedrine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acrivastine/Pseudoephedrine.

Important safety information:

• Acrivastine/Pseudoephedrine may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acrivastine/Pseudoephedrine. Using Acrivastine/Pseudoephedrine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Acrivastine/Pseudoephedrine. Acrivastine/Pseudoephedrine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• If you are having trouble sleeping, ask your pharmacist or doctor about the best time of day to take Acrivastine/Pseudoephedrine.


• Acrivastine/Pseudoephedrine contains an antihistamine and decongestant. Before you begin taking any new prescription or over-the-counter medicine, read the ingredients to see if it also contains an antihistamine, decongestant, or stimulant such as products used for dieting (appetite suppressants) or cold symptoms (eg, phenylephrine). If it does or if you are uncertain, contact your doctor or pharmacist.


• Diabetes patients - Acrivastine/Pseudoephedrine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.


• Use Acrivastine/Pseudoephedrine with caution in the ELDERLY because they may be more sensitive to its effects, especially if you already have trouble sleeping.


• Acrivastine/Pseudoephedrine is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Acrivastine/Pseudoephedrine during pregnancy. Acrivastine/Pseudoephedrine is excreted in breast milk. Do not breast-feed while taking Acrivastine/Pseudoephedrine.

Possible side effects of Acrivastine/Pseudoephedrine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; headache; nervousness; sleeplessness; sore throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast heartbeat; pounding in the chest.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acrivastine/Pseudoephedrine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast or irregular heartbeat; fever; hallucinations; nausea; seizures; sweating; tremors; trouble breathing; unusual drowsiness or dizziness; vomiting.

Proper storage of Acrivastine/Pseudoephedrine:

Store Acrivastine/Pseudoephedrine at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a dry place. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acrivastine/Pseudoephedrine out of the reach of children and away from pets.

General information:

• If you have any questions about Acrivastine/Pseudoephedrine, please talk with your doctor, pharmacist, or other health care provider.


• Acrivastine/Pseudoephedrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acrivastine/Pseudoephedrine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Acrivastine/Pseudoephedrine resources

• Acrivastine/Pseudoephedrine Side Effects (in more detail)
• Acrivastine/Pseudoephedrine Use in Pregnancy & Breastfeeding
• Acrivastine/Pseudoephedrine Drug Interactions
• Acrivastine/Pseudoephedrine Support Group
• 1 Review for Acrivastine/Pseudoephedrine - Add your own review/rating

Compare Acrivastine/Pseudoephedrine with other medications

• Hay Fever
• Nasal Congestion