Zarontin Solution

Pronunciation: ETH-oh-SUX-i-mide
Generic Name: Ethosuximide
Brand Name: Zarontin

Zarontin Solution is used for:

Controlling absence epilepsy (previously known as petit mal seizures). It may also be used for other conditions as determined by your doctor.

Zarontin Solution is an anticonvulsant. It acts in the brain to reduce the number of absence seizures.

Do NOT use Zarontin Solution if:

• you are allergic to any ingredient in Zarontin Solution or similar medicines

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zarontin Solution:

Some medical conditions may interact with Zarontin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have liver or kidney disease, lupus, or a blood disorder (eg, porphyria)


• if you have a history of mood or mental problems, including suicidal thoughts or attempts

Some MEDICINES MAY INTERACT with Zarontin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Zarontin Solution


• Valproic acid because it may affect the amount of Zarontin Solution in your blood

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zarontin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zarontin Solution:

Use Zarontin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Zarontin Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zarontin Solution refilled.


• Take Zarontin Solution by mouth with or without food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Taking Zarontin Solution at the same time each day will help you remember to take it. Take Zarontin Solution on a regular schedule to get the most benefit from it.


• Continue to take Zarontin Solution even if you feel well. Do not miss any doses.


• If you miss a dose of Zarontin Solution, take it as soon as possible. If it is almost time for you next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zarontin Solution.

Important safety information:

• Zarontin Solution may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zarontin Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zarontin Solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Increasing or decreasing the dose as well as adding or stopping other medicines should be done slowly. Rapidly stopping Zarontin Solution may suddenly make absence seizures worse.


• Zarontin Solution may cause swelling and tenderness of your gums. Brush and floss your teeth on a regular schedule and have regular dental checkups.


• Patients who take Zarontin Solution may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Zarontin Solution closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Lab tests, including complete blood cell counts, liver function, and kidney function tests, may be performed while you use Zarontin Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Zarontin Solution should not be used in CHILDREN younger than 3 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zarontin Solution while you are pregnant. Zarontin Solution is found in breast milk. If you are or will be breast-feeding while you use Zarontin Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zarontin Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; loss of appetite; nausea; stomach pain; stomach upset; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); increased number of seizures; lupus symptoms (eg, butterfly-shaped rash on the face, joint pain or swelling); new or worsening mood or mental changes (eg, depression); nightmares; red, swollen, blistered, or peeling skin; signs of infection (eg, fever, sore throat); suicidal thoughts or attempts; trouble concentrating; trouble sleeping; unusual bruising, bleeding, or fatigue.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zarontin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include central nervous system depression (eg, coma with slow, shallow breathing); nausea; vomiting.

Proper storage of Zarontin Solution:

Store Zarontin Solution below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not freeze. Keep Zarontin Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Zarontin Solution, please talk with your doctor, pharmacist, or other health care provider.


• Zarontin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zarontin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zarontin resources

• Zarontin Side Effects (in more detail)
• Zarontin Dosage
• Zarontin Use in Pregnancy & Breastfeeding
• Drug Images
• Zarontin Drug Interactions
• Zarontin Support Group
• 4 Reviews for Zarontin - Add your own review/rating

Compare Zarontin with other medications

• Seizures

pirbuterol inhaler

Generic Name: pirbuterol inhaler (peer BYOO ter ole)

Brand Names: Maxair, Maxair Autohaler

What is pirbuterol inhalation?

Pirbuterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.

Pirbuterol inhalation is used to treat conditions such as asthma, bronchitis, and emphysema.

Pirbuterol inhalation may also be used for conditions other than those listed in this medication guide.

What is the most important information I should know about pirbuterol inhalation?

It is very important that you use your pirbuterol inhaler properly, so that the medicine gets into your lungs. Your doctor may want you to use a spacer with your inhaler. Talk to your doctor about proper inhaler use.

Seek medical attention if you notice that you require more than your usual or more than the maximum amount of any asthma medication in a 24-hour period. An increased need for medication could be an early sign of a serious asthma attack.

Who should not use pirbuterol inhalation?

Before using this medication, tell your doctor if you have

• 
  

  heart disease or high blood pressure,

  
  


• 
  

  epilepsy or another seizure disorder,

  
  


• 
  

  diabetes,

  
  


• 
  

  an overactive thyroid (hyperthyroidism), or

  
  


• 
  

  any type of liver or kidney disease.

  
  

You may require a lower dose or special monitoring during therapy with pirbuterol if you have any of the conditions listed above.

Pirbuterol is in the FDA pregnancy category C. This means that it is not known whether pirbuterol inhalation will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. It is not known whether pirbuterol passes into breast milk. Do not use pirbuterol inhalation without first talking to your doctor if you are breast-feeding a baby. Pirbuterol inhalation is not approved for use by children younger than 12 years of age.

How should I use pirbuterol inhalation?

Take pirbuterol inhalation exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.

Shake the inhaler several times and uncap the mouthpiece. Breathe out fully and place your lips around the mouthpiece. Take a deep, slow breath as you push down on the canister. Hold your breath for several seconds, then exhale slowly.

The Autohaler releases the correct amount of drug. The force of your inhalation will trigger the release. You do not have to press down on a canister. Follow the instructions that accompany your inhaler.

If you take more than one dose at a time, wait for at least 1 full minute, then repeat the procedure.

Rinse your mouth after each use of the inhaler.

If you also use a steroid inhaler, use your pirbuterol inhaler first to open up your airways, then use the steroid inhaler as directed.

It is very important that you use your pirbuterol inhaler properly, so that the medicine gets into your lungs. Your doctor may want you to use a spacer with your inhaler. Talk to your doctor about proper inhaler use.

Seek medical attention if you notice that you require more than your usual or more than the maximum amount of any asthma medication in a 24-hour period. An increased need for medication could be an early sign of a serious asthma attack.

Keep your inhaler clean and dry. Keep the mouthpiece capped to avoid getting dirt inside it. Clean your inhaler once a day by removing the canister and mouthpiece and immersing it in warm water or alcohol. Allow the parts to dry, then reassemble the inhaler.

Carry your inhaler with you at all times in case of emergencies. Get a refill before you run out of medicine and before going on vacation.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a pirbuterol overdose include angina or chest pain, irregular heartbeats or a fluttering heart, seizures, tremor, weakness, headache, nausea, and vomiting.

What should I avoid while using pirbuterol inhalation?

Avoid situations that may trigger an asthma attack such as exercising in cold, dry air; smoking; breathing in dust; and exposure to allergens such as pet fur.

Pirbuterol inhalation side effects

Stop using pirbuterol and seek emergency medical attention if you experience any of the following serious side effects:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or

  
  


• 
  

  chest pain or irregular heartbeats.

  
  

Other, less serious side effects may be more likely to occur. Continue to use pirbuterol inhalation and talk to your doctor if you experience

• 
  

  headache, dizziness, lightheadedness, or insomnia;

  
  


• 
  

  tremor or nervousness;

  
  


• 
  

  sweating;

  
  


• 
  

  nausea, vomiting, or diarrhea; or

  
  


• 
  

  dry mouth.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Pirbuterol inhaler Dosing Information

Usual Adult Dose for Asthma -- Acute:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Adult Dose for Asthma -- Maintenance:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Acute:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Pediatric Dose for Asthma -- Acute:

>=12 years:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Pediatric Dose for Asthma -- Maintenance:

>=12 years:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Pediatric Dose for Chronic Obstructive Pulmonary Disease -- Acute:

>=12 years:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

Usual Pediatric Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

>=12 years:

2 puffs (0.4 mg) orally repeated every 4 to 6 hours. One puff (0.2 mg) repeated every 4 to 6 hours may be sufficient for some patients. A total daily dose of 12 inhalations should not be exceeded.

What other drugs will affect pirbuterol?

Before using this medication, tell your doctor if you are taking any of the following medicines:

• a beta-blocker (used to treat high blood pressure and other heart conditions) such as atenolol (Tenormin), metoprolol (Lopressor), or propranolol (Inderal). These medicines may greatly decrease the effects of pirbuterol and lead to an asthma attack.


• other commonly used beta-blockers, including acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard), and pindolol (Visken).


• a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), or nortriptyline (Pamelor). Very high blood pressure and other effects harmful to the heart may occur if these medicines are taken with pirbuterol.


• other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), and protriptyline (Vivactil).


• a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate). Very high blood pressure and other effects harmful to the heart may also occur if these medicines are taken with pirbuterol.


• 
  

  another inhaled bronchodilator such as albuterol (Ventolin, Proventil), bitolterol (Tornalate), isoetharine (Bronkometer, Bronkosol), isoproterenol (Isuprel, Medihaler-Iso), metaproterenol (Alupent, Metaprel), salmeterol (Servent), or terbutaline (Brethaire, Brethine, Bricanyl). Using other inhaled medicines to open up your lungs will increase the risk of damage to your heart when you are taking pirbuterol.

  
  


• 
  

  caffeine, diet pills, or decongestants. These may also increase heart-related side effects.

  
  

Drugs other than those listed here may also interact with pirbuterol inhalation, or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More pirbuterol inhaler resources

• Pirbuterol inhaler Side Effects (in more detail)
• Pirbuterol inhaler Dosage
• Pirbuterol inhaler Use in Pregnancy & Breastfeeding
• Pirbuterol inhaler Drug Interactions
• Pirbuterol inhaler Support Group
• 5 Reviews for Pirbuterol inhaler - Add your own review/rating

Compare pirbuterol inhaler with other medications

• Asthma, acute
• Asthma, Maintenance
• COPD, Acute
• COPD, Maintenance

Where can I get more information?

• Your pharmacist has additional information about pirbuterol written for health professionals that you may read.

See also: pirbuterol inhaler side effects (in more detail)

Codeine/Guaifenesin/Pseudoephedrine Liquid

Pronunciation: KOE-deen/gwye-FEN-e-sin/SOO-doe-e-FED-rin
Generic Name: Codeine/Guaifenesin/Pseudoephedrine
Brand Name: Examples include Mytussin DAC and Robitussin DAC

Codeine/Guaifenesin/Pseudoephedrine Liquid is used for:

Relieving congestion and cough due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Codeine/Guaifenesin/Pseudoephedrine Liquid is a decongestant, cough suppressant, and expectorant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough. The expectorant loosens mucus and lung secretions in the chest and makes coughs more productive.

Do NOT use Codeine/Guaifenesin/Pseudoephedrine Liquid if:

• you are allergic to any ingredient in Codeine/Guaifenesin/Pseudoephedrine Liquid or any other codeine- or morphine-related medicine (eg, oxycodone)


• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)


• you are having an asthma attack


• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Codeine/Guaifenesin/Pseudoephedrine Liquid:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to morphine, codeine, or any other opiate (eg, hydrocodone, dihydrocodeine, oxycodone)


• if you have a history of glaucoma; an enlarged prostate gland or other prostate problems; heart problems; diabetes; high blood pressure; blood vessel problems; stroke; liver or kidney problems; blockage of the stomach, bowel, or bladder; adrenal gland problems; or thyroid problems


• if you have a history of constipation, stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent stomach, bowel, or urinary surgery


• if you have breathing or lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if you have a cough that occurs with large amounts of mucus


• if you have a fever, severe drowsiness, recent head or brain injury, brain tumor, increased pressure in the brain, infection of the brain or nervous system, or a seizure disorder (eg, epilepsy)


• if you have very poor health or a history of alcohol abuse, other substance abuse, or suicidal thoughts or actions


• if you are taking medicine for high blood pressure or depression

Some MEDICINES MAY INTERACT with Codeine/Guaifenesin/Pseudoephedrine Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), cimetidine, furazolidone, HIV protease inhibitors (eg, ritonavir), indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Codeine/Guaifenesin/Pseudoephedrine Liquid's side effects


• Naltrexone, quinidine, or rifamycins (eg, rifampin) because they may decrease Codeine/Guaifenesin/Pseudoephedrine Liquid's effectiveness


• Bromocriptine or sodium oxybate (GHB) because the risk of their side effects may be increased by Codeine/Guaifenesin/Pseudoephedrine Liquid


• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Codeine/Guaifenesin/Pseudoephedrine Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Codeine/Guaifenesin/Pseudoephedrine Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Codeine/Guaifenesin/Pseudoephedrine Liquid:

• Take Codeine/Guaifenesin/Pseudoephedrine Liquid by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Drink plenty of water while taking Codeine/Guaifenesin/Pseudoephedrine Liquid.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Codeine/Guaifenesin/Pseudoephedrine Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Codeine/Guaifenesin/Pseudoephedrine Liquid.

Important safety information:

• Codeine/Guaifenesin/Pseudoephedrine Liquid may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Codeine/Guaifenesin/Pseudoephedrine Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Codeine/Guaifenesin/Pseudoephedrine Liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Codeine/Guaifenesin/Pseudoephedrine Liquid may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do not take diet or appetite control medicines while you are taking Codeine/Guaifenesin/Pseudoephedrine Liquid without checking with your doctor.


• Codeine/Guaifenesin/Pseudoephedrine Liquid has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better within 5 days, if they get worse, or if they go away and then come back, check with your doctor.


• If your symptoms occur along with fever, rash, or persistent headache, contact your doctor.


• Do not use Codeine/Guaifenesin/Pseudoephedrine Liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.


• Codeine/Guaifenesin/Pseudoephedrine Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Codeine/Guaifenesin/Pseudoephedrine Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Codeine/Guaifenesin/Pseudoephedrine Liquid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Codeine/Guaifenesin/Pseudoephedrine Liquid.


• Tell your doctor or dentist that you take Codeine/Guaifenesin/Pseudoephedrine Liquid before you receive any medical or dental care, emergency care, or surgery.


• Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.


• Use Codeine/Guaifenesin/Pseudoephedrine Liquid with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, low blood pressure, excitability, dry mouth, and trouble urinating.


• Caution is advised when using Codeine/Guaifenesin/Pseudoephedrine Liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.


• Codeine/Guaifenesin/Pseudoephedrine Liquid should not be used in CHILDREN younger than 6 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Codeine/Guaifenesin/Pseudoephedrine Liquid while you are pregnant. Codeine/Guaifenesin/Pseudoephedrine Liquid is found in breast milk. Do not breast-feed while taking Codeine/Guaifenesin/Pseudoephedrine Liquid.

Possible side effects of Codeine/Guaifenesin/Pseudoephedrine Liquid:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating; fainting; fast, slow, or irregular heartbeat; hallucinations; mental or mood changes; persistent trouble sleeping; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow breathing; tremor; uncontrolled muscle movement.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Codeine/Guaifenesin/Pseudoephedrine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow or rapid breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Codeine/Guaifenesin/Pseudoephedrine Liquid:

Store Codeine/Guaifenesin/Pseudoephedrine Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Codeine/Guaifenesin/Pseudoephedrine Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Codeine/Guaifenesin/Pseudoephedrine Liquid, please talk with your doctor, pharmacist, or other health care provider.


• Codeine/Guaifenesin/Pseudoephedrine Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Codeine/Guaifenesin/Pseudoephedrine Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Codeine/Guaifenesin/Pseudoephedrine resources

• Codeine/Guaifenesin/Pseudoephedrine Side Effects (in more detail)
• Codeine/Guaifenesin/Pseudoephedrine Use in Pregnancy & Breastfeeding
• Codeine/Guaifenesin/Pseudoephedrine Drug Interactions
• Codeine/Guaifenesin/Pseudoephedrine Support Group
• 1 Review for Codeine/Guaifenesin/Pseudoephedrine - Add your own review/rating

Compare Codeine/Guaifenesin/Pseudoephedrine with other medications

• Cold Symptoms

Aspergillosis, Meningitis Medications

There are currently no drugs listed for "Aspergillosis, Meningitis".

Learn more about Aspergillosis, Meningitis

Medical Encyclopedia:

• Aspergillosis

Drug List:

Fluoxetine Capsules 20 mg

1. Name Of The Medicinal Product

Fluoxetine Capsules 20 mg.

2. Qualitative And Quantitative Composition

Each capsule contains fluoxetine 20 mg as fluoxetine hydrochloride.

3. Pharmaceutical Form

Capsule.

Hard gelatin capsule, size 3.

Capsule cap is light green opaque. Capsule body is light green opaque.

Capsule contains an almost white powder. Capsule is marked “F20”.

4. Clinical Particulars

4.1 Therapeutic Indications

For the treatment of symptoms of depressive illness, with or without anxiety symptoms, especially when sedation is not required; obsessive-compulsive disorder, and for the symptoms of bulimia nervosa in adults.

4.2 Posology And Method Of Administration

Fluoxetine may be administered as a single or divided dose, during or between meals.

Adults and the elderly:

Depression: The recommended dose is 20mg daily.

Obsessive-compulsive disorder: The recommended initial dose is 20mg daily, thereafter up to 60mg daily may be prescribed after several weeks if a positive response is not obtained with the initial dose.

Bulimia nervosa: The recommended dose is 60mg daily.

Unwanted effects may be more evident at higher doses.

Patients with renal or hepatic dysfunction:

A lower dose, or alternate day dosing, is recommended for patients with hepatic dysfunction or mild to moderate renal failure (i.e. with a glomerular filtrate rate of between 10ml and 50ml per minute). Fluoxetine is contra-indicated in patients with severe renal failure as accumulation may occur in this group during chronic treatment.

Children:

Fluoxetine Capsules 20mg are not recommended for children.

Steady state plasma levels of fluoxetine are only achieved after continued dosing for several weeks. When the patient stops taking fluoxetine the drug will also persist in the body for several weeks.

Method of administration: oral.

Withdrawal symptoms seen on discontinuation of SSRI

Abrupt discontinuation should be avoided. When stopping treatment with fluoxetine the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see sections 4.4 Special warnings and precautions for use and 4.8 Undesirable effects). If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose, but at a more gradual rate.

4.3 Contraindications

Fluoxetine is contra-indicated in the following circumstances:

- hypersensitivity to fluoxetine or any of the other ingredients,

- in breast-feeding mothers,

- in unstable or uncontrolled epilepsy,

- in severe renal failure (i.e. GFR <10ml/minute), or

- if the patient has been taking monoamine oxidase inhibitors (MAOIs) within the past 2 weeks due to the “serotonin syndrome", see section 4.5. Interactions.

4.4 Special Warnings And Precautions For Use

Suicide/suicidal thoughts or clinical worsening

Depression is associated with an increased risk of suicidal thoughts, self harm and suicide (suicide

Other psychiatric conditions for which fluoxetine is prescribed can also be associated with an increased risk of suicide

Patients with a history of suicide

Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes. Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.

If a rash or other allergic reaction such as urticaria or angioneurotic oedema occurs, fluoxetine should be discontinued, unless an alternative cause can be identified.

Fluoxetine must be discontinued in patients who start having seizures. Fluoxetine should be avoided in patients suffering with unstable epilepsy. Patients with controlled epilepsy should be carefully monitored as prolonged seizures have been reported in this group.

A lower dose, e.g. alternate day dosing, is recommended in patients with significant hepatic impairment or mild to moderate renal failure (GFR 10-50ml/minute) as fluoxetine is extensively metabolised hepatically and excreted renally.

Caution is advised in patients with acute cardiac disease as clinical experience is limited.

Fluoxetine may cause weight loss which may not be desirable in underweight patients who are depressed, although only rarely has fluoxetine been discontinued in patients with depression or bulimia due to this.

Fluoxetine may alter blood glucose control in patients with diabetes. Hypoglycaemia has occurred during treatment with fluoxetine. Hyperglycaemia has developed after discontinuation of fluoxetine. Diabetic patients taking insulin with or without other hypoglycaemic therapy may need to have their dosages of insulin and/or hypoglycaemic drugs adjusted.

Psychosis and mood shift towards manic phase have been reported which may require discontinuation of treatment.

Abrupt discontinuation of treatment should be avoided. Withdrawal reactions have been reported in association with selective serotonin reuptake inhibitors (SSRIs) including fluoxetine, common symptoms include headache, dizziness, paraesthesia, anxiety and nausea. The majority of symptoms experienced on withdrawal of SSRIs are non-serious and self limiting.

There is little clinical experience of concurrent administration of SSRI's and electroconvulsive therapy (ECT), therefore caution is advised.

There have been reports of cutaneous bleeding abnormalities such as ecchymoses and purpura with SSRI's. Caution is advised in patients taking SSRI's, particularly in concomitant use with drugs known to affect platelet function (e.g. atypical antipsychotics and phenothiazines, most tricyclic antidepressants, aspirin and NSAID's) as well as in patients with a history of bleeding disorders.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The long elimination time needs to be borne in mind when considering drug interactions.

Fluoxetine binds to plasma protein and concurrent administration may alter plasma concentrations of other plasma protein-bound drugs, or vice versa. In tests, no drug interaction of clinical significance was observed between fluoxetine and chlorothiazide, ethanol, tolbutamide or secobarbital.

Monoamine oxidase inhibitors: at least 14 days should elapse between discontinuation of monoamine oxidase inhibitors (MAOIs) and initiation of treatment with Fluoxetine Capsules. Conversely, at least 5 weeks should elapse between discontinuation of fluoxetine and initiation of therapy with an MAOI. NB this period should be longer if fluoxetine has been prescribed chronically or at higher doses. The serotonin syndrome, i.e. serious, sometimes fatal reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation, progressing to delirium and coma) have been reported with concomitant use of MAOIs and fluoxetine or when fluoxetine had been recently discontinued and an MAOI started. Some patients developed features resembling neuroleptic malignant syndrome in which case cyproheptadine or dantrolene may be beneficial.

CNS active drugs such as lithium should be administered with caution with fluoxetine. Reports have been made of both increased and decreased lithium levels and also of lithium toxicity. Levels of lithium should be monitored.

As fluoxetine is metabolised by the hepatic cytochrome CY3PA and P450IID6 isoenzymes, co-administration of other drugs similarly metabolised may lead to drug interactions. Drugs such as flecainide, encainide, vinblastine, carbamazepine and tricyclic antidepressants which have a narrow therapeutic index should be started at a low dose when taken at the same time as fluoxetine or within 5 weeks of stopping fluoxetine. More than 2-fold increases in previously stable plasma levels of tricyclic antidepressants have been seen when fluoxetine has been concomitantly administered.

Restlessness, agitation and gastro-intestinal symptoms have been reported in a small number of patients receiving fluoxetine at the same time as tryptophan.

Patients, previously stable on phenytoin, have developed raised plasma levels of phenytoin and clinical phenytoin toxicity following the start of concomitant fluoxetine therapy.

No drug interaction between fluoxetine and warfarin has been observed in formal testing. However, possible interactions have been rarely reported.

Fluoxetine does not seem to potentiate the effects of alcohol.

Dynamic interactions between fluoxetine and the herbal remedy, St. John's wort (Hypericum perforatum) can occur, resulting in an increase in undesirable effects.

4.6 Pregnancy And Lactation

The safety of fluoxetine has not been established during pregnancy, and therefore its use is not recommended. Fluoxetine is contra-indicated in breast-feeding mothers as breast milk has been found to contain fluoxetine and norfluoxetine.

4.7 Effects On Ability To Drive And Use Machines

Fluoxetine does not seem to affect psychomotor performance. However, if patients find that their concentration is impaired, or they feel tired or dizzy, they should not drive or operate machines.

4.8 Undesirable Effects

General: Asthenia, fever, loss of appetite, weight loss, or hair loss (usually reversible). Rare reports of hyponatraemia (including serum sodium below 110 mmol/litre) have been made which appeared to be reversible on discontinuation of fluoxetine; some cases may have been due to inappropriate ADH secretion. Most reports of hyponatraemia were associated with elderly patients, or patients taking diuretics or who were otherwise volume depleted.

Allergic reactions: see Skin and appendages.

Digestive system: dry mouth, dyspepsia, nausea, vomiting, or diarrhoea.

Hepatic system: abnormal liver function tests have been rarely reported.

Nervous system: the following effects have been reported: headache, nervousness, fatigue, drowsiness, insomnia, anxiety, tremor, dizziness, seizures, hypomania or mania, dyskinesia, movement disorders in patients with risk factors (including drugs associated with movement disorders), worsening of pre-existing movement disorders, or neuroleptic malignant syndrome-like events.

Reproductive system: decreased libido or sexual dysfunction (delayed or inhibited orgasm) may occur.

Respiratory system: pharyngitis or dyspnoea. Rare reports of pulmonary events with dyspnoea as the only preceding symptom (including various inflammatory processes and/or fibrosis) have been made.

Skin and appendages: a small percentage of patients developed rash and/or urticaria. Serious systemic reactions, possibly related to vasculitis, have developed in patients with rash, and rarely death has been reported. Hyperhidrosis, arthralgia, myalgia, serum sickness and anaphylactoid reactions have also been reported. If a rash or other allergic reaction occurs such as urticaria or angioneurotic oedema, fluoxetine should be discontinued, unless an alternative cause can be identified.

The following have been reported in association with fluoxetine but no causal relationship has been established: abnormal bleeding, anaemia (aplastic and immune-related haemolytic), cerebrovascular accident, confusion, ecchymoses, eosinophilic pneumonia, gastrointestinal haemorrhage, hyperprolactinaemia, pancreatitis, pancytopenia, purpura, thrombocytopenia, vaginal bleeding after drug withdrawal and violent behaviour.

Cases of suicidal ideation and suicidal behaviours have been reported during fluoxetine therapy or early after treatment discontinuation (see section 4.4).

4.9 Overdose

The fatal dose is not known. The effects will be potentiated by alcohol taken at the same time. Toxicity is also potentiated by tricyclic antidepressants and MAOIs.

Symptoms

Nausea, vomiting, agitation, tremor, nystagmus and drowsiness may occur. Convulsions have been reported in a small percentage of cases and may not occur until up to ten hours after ingestion. Sinus tachycardia is common. Less frequently bradycardia, hypertension and junctional rhythm may occur.

Rarely features of the "serotonin syndrome" may occur. This includes alteration of mental status, neuromuscular hyperactivity and autonomic instability. There may be hyperpyrexia and elevation of serum creatine kinase. Rhabdomyolysis is rare.

Management

Consider oral activated charcoal if more than 500 mg has been ingested by an adult or if more than 5 mg/kg has been ingested by a child within one hour. Management should be symptomatic and supportive and include the maintenance of a clear airway and monitoring of cardiac and vital signs until stable.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

ATC Code: N06A B03.

Fluoxetine is a specific serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor.

5.2 Pharmacokinetic Properties

Fluoxetine is readily absorbed from the gastro-intestinal tract with peak plasma levels approximately 6-8 hours after oral administration, although steady state plasma concentrations do not occur until after several weeks. Fluoxetine is widely distributed throughout the body and is extensively bound to plasma proteins.

The drug is largely metabolised hepatically to its primary metabolite, norfluoxetine. Fluoxetine has an elimination half-life of about 1-6 days depending on type of administration (acute 1-3 days, chronic 4-6 days). Norfluoxetine's elimination half-life is approximately 4-16 days after multiple doses. This is of clinical significance as after the patient has stopped taking fluoxetine, the active substance and its metabolites may remain in the body for weeks. Excretion is mainly via the kidneys.

5.3 Preclinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included in the other sections of the Summary of Product Characteristics.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Pregelatinised maize starch, anhydrous colloidal silica, magnesium stearate, talc, quinoline yellow (E104), indigo carmine (E132), titanium dioxide (E171) and gelatin.

6.2 Incompatibilities

None known.

6.3 Shelf Life

Blister packs: 24 months. HDPE bottles: 36 months.

6.4 Special Precautions For Storage

Blister pack: Do not store above 25°C. Store in the original package.

HDPE bottle: No special storage recommendations.

6.5 Nature And Contents Of Container

i) Aluminium/PVC blister strips packed in an outer carton, or

ii) A high density polyethylene bottle with low density polyethylene snap-on cap.

Pack sizes: 28 and 30.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Sandoz Limited

Woolmer Way

Bordon

Hampshire

GU35 9QE

United Kingdom

8. Marketing Authorisation Number(S)

PL 04416/0330

9. Date Of First Authorisation/Renewal Of The Authorisation

05/03/2009

10. Date Of Revision Of The Text

27/07/2009

Lupron

Generic Name: leuprolide (LOO proe lide)

Brand Names: Eligard, Lupron, Lupron Depot, Lupron Depot-Gyn, Lupron Depot-Ped

What is leuprolide?

Leuprolide is a man-made form of a hormone that regulates many processes in the body. Leuprolide overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone in men or estrogen in women.

Leuprolide is used in men to treat the symptoms of prostate cancer. Leuprolide treats only the symptoms of prostate cancer and does not treat the cancer itself. Use any other medications your doctor has prescribed to best treat your condition.

Leuprolide is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

Leuprolide is also used to treat precocious (early-onset) puberty in both male and female children.

Leuprolide may also be used for purposes not listed in this medication guide.

What is the most important information I should know about leuprolide?

Leuprolide can harm an unborn baby or cause birth defects. Do not use if you are pregnant. You should not breast-feed while you are using leuprolide. You should not use this medication if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), or nafarelin (Synarel). You should not use leuprolide if you have abnormal vaginal bleeding that has not been diagnosed by a doctor.

Before using leuprolide, tell your doctor if you have epilepsy, asthma, migraines, heart or kidney disease, a history of depression, osteoporosis, bone cancer affecting your spine, blood in your urine, or if you are unable to urinate.

Tell your doctor if you have a personal or family history of osteoporosis, or if you have any risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term. Long-term use of this medication may decrease bone density, possibly leading to osteoporosis.

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medication to make sure you have received the correct brand and strength prescribed by your doctor.

What should I discuss with my healthcare provider before using leuprolide?

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medication to make sure you have received the correct brand and strength prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. You should not use this medication if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), nafarelin (Synarel), or if you have:

• 
  

  abnormal vaginal bleeding that has not been diagnosed by a doctor; or

  
  


• 
  

  if you are pregnant or breast-feeding.

  
  

Do not breast-feed a baby while using leuprolide.

To make sure you can safely use leuprolide, tell your doctor if you have any of these other conditions:

• 
  

  a personal or family history of osteoporosis;

  
  


• 
  

  risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term;

  
  


• 
  

  diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);

  
  


• 
  

  epilepsy;

  
  


• 
  

  asthma;

  
  


• 
  

  migraines;

  
  


• 
  

  kidney disease;

  
  


• 
  

  a history of depression;

  
  


• 
  

  bone cancer affecting your spine;

  
  


• 
  

  blood in your urine; or

  
  


• 
  

  if you are unable to urinate.

  
  

FDA pregnancy category X. This medication can cause birth defects. Do not use leuprolide if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Leuprolide usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use an effective barrier form of birth control (such as a condom or diaphragm with spermicide gel or inserts). Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective in preventing pregnancy while you are using leuprolide.

Because leuprolide is expected to cause your menstrual periods to stop, contact your doctor if your periods continue while you are being treated with this medication.

Long-term use of this medication may decrease bone density, possibly leading to osteoporosis. Talk with your doctor about your possible risk for osteoporosis. You may need to receive a bone scan if you ever need to be re-treated with leuprolide in the future.

How should I use leuprolide?

Leuprolide is injected under the skin or into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Leuprolide may be given once every month or once every 3 to 6 months. How often you receive this medication will depend on the condition being treated. Follow your doctor's instructions.

Because different brands or strengths of leuprolide are used to treat different conditions, it is very important that you receive exactly the brand and strength your doctor has prescribed. If you self-inject this medication at home, always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Your symptoms may become temporarily worse as your hormones adjust when you first start using this medication. For best results, keep using the medication as instructed by your doctor. Your condition should eventually improve with continued use of leuprolide.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with leuprolide. You may still need blood tests for up to 3 months after you stop using leuprolide to check your hormone levels and pituitary gland function. Do not miss any scheduled appointments.

Store Lupron in the original carton at room temperature, away from moisture and heat. Store Eligard in the refrigerator. Do not freeze. You may take the medicine out and allow it to reach room temperature before mixing and injecting your dose. After the dose is mixed, you must use the injection within 30 minutes.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

Women who miss more than one leuprolide dose may have breakthrough bleeding. Children who miss more than one dose may have a return of pubertal symptoms such as breast development, growth in the testicles, or menstrual periods.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weakness, or irritation where the leuprolide shot was given.

What should I avoid while using leuprolide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Leuprolide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  bone pain, loss of movement in any part of your body;

  
  


• 
  

  swelling, rapid weight gain;

  
  


• 
  

  pain, burning, stinging, bruising, or redness where the medication was injected;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  painful or difficult urination;

  
  


• 
  

  urinating more often than usual;

  
  


• 
  

  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  
  


• 
  

  sudden numbness or weakness (especially on one side of the body), problems with speech or balance;

  
  


• 
  

  sudden headache with vision problems, vomiting, confusion, slow heart rate, weak pulse, fainting, or slow breathing; or

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

  
  

Rare but serious side effects may include:

• 
  

  pain or unusual sensations in your back;

  
  


• 
  

  numbness, weakness, or tingly feeling in your legs or feet;

  
  


• 
  

  muscle weakness or loss of use; and

  
  


• 
  

  loss of bowel or bladder control.

  
  

Less serious side effects may include:

• 
  

  acne, increased growth of facial hair;

  
  


• 
  

  breakthrough bleeding in a female child during the first 2 months of leuprolide treatment;

  
  


• 
  

  dizziness, weakness, tired feeling;

  
  


• 
  

  hot flashes, night sweats, chills, clammy skin;

  
  


• 
  

  nausea, diarrhea, constipation, stomach pain;

  
  


• 
  

  skin redness, itching, or scaling;

  
  


• 
  

  joint or muscle pain;

  
  


• 
  

  vaginal itching or discharge

  
  


• 
  

  breast swelling or tenderness;

  
  


• 
  

  testicle pain;

  
  


• 
  

  impotence, loss of interest in sex;

  
  


• 
  

  depression, sleep problems (insomnia), memory problems; or

  
  


• 
  

  redness, burning, stinging, or pain where the shot was given.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect leuprolide?

There may be other drugs that can interact with leuprolide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Lupron resources

• Lupron Side Effects (in more detail)
• Lupron Use in Pregnancy & Breastfeeding
• Lupron Drug Interactions
• Lupron Support Group
• 12 Reviews for Lupron - Add your own review/rating

• Lupron Advanced Consumer (Micromedex) - Includes Dosage Information


• Lupron Consumer Overview


• Lupron MedFacts Consumer Leaflet (Wolters Kluwer)


• Leuprolide Prescribing Information (FDA)


• Eligard Prescribing Information (FDA)


• Eligard Consumer Overview


• Eligard Kit MedFacts Consumer Leaflet (Wolters Kluwer)


• Leuprolide Acetate Monograph (AHFS DI)


• Lupron Depot Prescribing Information (FDA)


• Lupron Depot MedFacts Consumer Leaflet (Wolters Kluwer)


• Lupron Depot-PED Prescribing Information (FDA)


• Lupron Depot-PED Kit MedFacts Consumer Leaflet (Wolters Kluwer)


• Viadur Prescribing Information (FDA)


• Viadur Implant MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Lupron with other medications

• Breast Cancer, Adjuvant
• Endometriosis
• Hirsutism
• Prostate Cancer
• Uterine Fibroids

Where can I get more information?

• Your pharmacist can provide more information about leuprolide.

See also: Lupron side effects (in more detail)

Serotoninergic neuroenteric modulators

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Serotoninergic neuroenteric modulators bind to the serotonin receptors in the gastrointestinal tract and either act as an agonist or antagonist.

One of the agents in this class is a selective serotonin receptor antagonist, so it binds to the serotonin receptor and blocks the action of serotonin in the gastrointestinal tract. The agent with serotonin receptor antagonist activity is used to relieve cramping, abdominal discomfort, diarrhea, etc. associated with irritable bowel syndrome.

The other agents in this category are selective serotonin receptor agonists that act in the gastrointestinal tract to regulate bowel function. It is used to treat chronic constipation and constipation related to irritable bowel syndrome.

See also

Medical conditions associated with serotoninergic neuroenteric modulators:

• Constipation, Chronic
• Diarrhea
• Irritable Bowel Syndrome

Drug List:

Zelnorm

Lotronex